Rotavirus (RV) is the primary etiological agent of virus-associated gastroenteritis in infants,
causing 200,000 childhood death annually. Despite the availability of vaccines, rotaviral …

Rotaviruses (RVs) are the leading cause of severe gastroenteritis in young children,
accounting for half a million deaths annually worldwide. RV encodes non-structural protein 1 …

Like many viruses, rotavirus (RV) dysregulates calcium homeostasis by elevating cytosolic
calcium ([Ca2+] cyt) and decreasing endoplasmic reticulum (ER) stores. While an overall …

Replication of many RNA viruses benefits from subversion of the autophagic pathway
through many different mechanisms. Rotavirus, the main etiologic agent of pediatric …

Human rotaviruses are the utmost etiologic agents of infantile gastroenteritis in children
under five years of age. To reduce childhood morbidity and mortality caused by this rotavirus …

Rotavirus (RV)-encoded nonstructural protein 1 (NSP1), the product of gene segment 5,
effectively antagonizes host interferon (IFN) signaling via multiple mechanisms. Recent …

Our understanding of how rotavirus (RV) subverts host innate immune signaling has greatly
increased over the past decade. However, the relative contribution of each virus-encoded …

The rotavirus nonstructural protein 1 (NSP1) antagonizes interferon (IFN) induction in
infected host cells. The primary function of NSP1 is thought to be degradation of interferon …

Murine hepatitis virus strain A59 (MHV-A59) was shown to induce pyroptosis, apoptosis, and
necroptosis of infected cells, especially in the murine macrophages. However, whether …

INTRODUCTION Rotavirus (RV) causes severe diarrheal disease in children worldwide by
broadly dysregulating intestinal homeostasis. The mechanisms of RV diarrhea are …