Mechanism of lung injury caused by PM10 and ultrafine particles with special reference to COPD

W MacNee, K Donaldson - European Respiratory Journal, 2003 - Eur Respiratory Soc
Particulate air pollution (particles with a 50% cut-off aerodynamic diameter of 10 µm (PM
10)) has strong associations with the adverse health events detected by epidemiological …

Potential mechanisms of adverse pulmonary and cardiovascular effects of particulate air pollution (PM10)

K Donaldson, W MacNee - … Journal of Hygiene and Environmental Health, 2001 - Elsevier
PM10 is the international convention for measuring environmental particulate air pollution.
Increases in PM10 have been linked to exacerbations of airways disease and deaths from …

Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung

E André, T Stoeger, S Takenaka… - European …, 2006 - Eur Respiratory Soc
High levels of particulate matter in ambient air are associated with increased respiratory and
cardiovascular health problems. It has been hypothesised that it is the ultrafine particle …

Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro.

XY Li, PS Gilmour, K Donaldson, W MacNee - Thorax, 1996 - thorax.bmj.com
BACKGROUND: Epidemiological evidence has implicated fine particulate air pollution,
particularly particles less than 10 microns in diameter (PM10), in the development of …

The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types

CAJ Dick, DM Brown, K Donaldson, V Stone - Inhalation toxicology, 2003 - Taylor & Francis
PM 10 contains an ultrafine component, which is generally derived from combustion
processes. This ultrafine fraction may be a factor in the increases in exacerbations of …

Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium

W Möller, DM Brown, WG Kreyling, V Stone - Particle and fibre toxicology, 2005 - Springer
Background Particulate air pollution is reported to cause adverse health effects in
susceptible individuals. Since most of these particles are derived form combustion …

The pulmonary toxicology of ultrafine particles

K Donaldson, D Brown, A Clouter, R Duffin… - Journal of aerosol …, 2002 - liebertpub.com
Ultrafine particles are a component of air pollution, derived from primary combustion
sources, and so we have undertaken a programme of study on the mechanisms of lung …

Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin

A CP Elder, R Gelein, J N. Finkelstein, C Cox… - Inhalation …, 2000 - Taylor & Francis
Epidemiological studies demonstrate associations between increasing levels of ambient
particles and morbidity in the elderly with cardiopulmonary disease. Such findings have …

Reactive oxygen species in pulmonary inflammation by ambient particulates

F Tao, B Gonzalez-Flecha, L Kobzik - Free Radical Biology and Medicine, 2003 - Elsevier
Exposure to ambient air pollution particles (PM) has been associated with increased
cardiopulmonary morbidity and mortality, particularly in individuals with pre-existing disease …

Pulmonary effects of inhaled ultrafine particles

G Oberdörster - … archives of occupational and environmental health, 2000 - Springer
Abstract Introduction and Objectives: Recent epidemiological studies have shown an
association between increased particulate urban air pollution and adverse health effects on …