Comparison of atezolizumab plus bevacizumab and lenvatinib in terms of efficacy and safety as primary systemic chemotherapy for hepatocellular carcinoma

K Maesaka, R Sakamori, R Yamada, A Doi… - Hepatology …, 2022 - Wiley Online Library
Aim Atezolizumab plus bevacizumab and lenvatinib have each shown efficacy as primary
systemic chemotherapies for hepatocellular carcinoma (HCC) in clinical trials. However …

[HTML][HTML] First-line immune checkpoint inhibitor-based sequential therapies for advanced hepatocellular carcinoma: rationale for future trials

G Cabibbo, M Reig, C Celsa, F Torres, S Battaglia… - Liver Cancer, 2022 - karger.com
Introduction: Atezolizumab (ATEZO) plus bevacizumab (BEVA) represents the new standard
of care for the treatment of advanced hepatocellular carcinoma (HCC). However, the choice …

Atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma: Early clinical experience

A Hiraoka, T Kumada, T Tada, M Hirooka… - Cancer …, 2022 - Wiley Online Library
Background Although atezolizumab plus bevacizumab (Atez/bev) treatment has been
developed for unresectable hepatocellular carcinoma (u‐HCC), changes in hepatic function …

[HTML][HTML] Sequential therapies after atezolizumab plus bevacizumab or lenvatinib first-line treatments in hepatocellular carcinoma patients

M Persano, M Rimini, T Tada, G Suda… - European Journal of …, 2023 - Elsevier
Introduction The aim of this retrospective proof-of-concept study was to compare different
second-line treatments for patients with hepatocellular carcinoma and progressive disease …

Atezolizumab and bevacizumab combination compared with sorafenib as the first‐line systemic treatment for patients with unresectable hepatocellular carcinoma: a …

F Wen, H Zheng, P Zhang, W Liao, K Zhou… - Liver …, 2021 - Wiley Online Library
Abstract Background & Aims In patients with unresectable hepatocellular carcinoma (HCC),
the combination of atezolizumab and bevacizumab improved progression‐free survival …

Characterization of response to atezolizumab+ bevacizumab versus sorafenib for hepatocellular carcinoma: Results from the IMbrave150 trial

R Salem, D Li, N Sommer, S Hernandez… - Cancer …, 2021 - Wiley Online Library
Background IMbrave150 is a phase III trial that assessed atezolizumab+ bevacizumab
(ATEZO/BEV) versus sorafenib (SOR) in patients with unresectable hepatocellular …

Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma

JM Llovet, R Pinyol, M Yarchoan, AG Singal… - Nature Reviews …, 2024 - nature.com
Liver cancer, specifically hepatocellular carcinoma (HCC), is the sixth most common cancer
and the third leading cause of cancer mortality worldwide. The development of effective …

Early tumor response and safety of atezolizumab plus bevacizumab for patients with unresectable hepatocellular carcinoma in real-world practice

Y Ando, T Kawaoka, M Kosaka, Y Shirane, Y Johira… - Cancers, 2021 - mdpi.com
Simple Summary Although atezolizumab plus bevacizumab combination therapy was
approved in September 2020 as the first immune-combined therapy for hepatocellular …

[PDF][PDF] Achievement of complete response and drug-free status by atezolizumab plus bevacizumab combined with or without curative conversion in patients with …

M Kudo, T Aoki, K Ueshima, K Tsuchiya, M Morita… - Liver cancer, 2023 - karger.com
Introduction: Atezolizumab plus bevacizumab therapy is extremely effective in the treatment
of intermediate-stage hepatocellular carcinoma (HCC), with a response rate of 44%, as …

Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial

J Bruix, T Takayama, V Mazzaferro, GY Chau… - The lancet …, 2015 - thelancet.com
Background There is no standard of care for adjuvant therapy for patients with
hepatocellular carcinoma. This trial was designed to assess the efficacy and safety of …