The disposition of many medications is altered during pregnancy. Due to changes in many
physiological parameters as well as variability in the activity of maternal drug-metabolizing …

Significant changes in the physiological and biotransformation processes that govern
pharmacokinetics occur during pregnancy. Consequently, the disposition of many …

Pharmacologic interventions play a major role in obstetrical care throughout pregnancy,
labor and delivery and the postpartum. Traditionally, obstetrical providers have utilized …

Essentially all drugs taken by a pregnant woman are transferred across the placenta to the
fetus. Fetal drug exposure, as reflected by the unbound (free) drug concentration versus time …

Pregnancy is associated with a variety of physiological changes that can alter the
pharmacokinetics and pharmacodynamics of several drugs. However, limited data exists on …

Any drug given to a pregnant woman must be considered as possibly harmful to the fetus,
since all drugs administered to the mother cross the placental membrane, although at …

The dynamic physiological changes that occur in the maternal-placental-fetal unit during
pregnancy influence the pharmacokinetic processes of drug absorption, distribution and …

Importance of the field: Medication use during pregnancy is prevalent, but pharmacokinetic
information of most drugs used during pregnancy is lacking in spite of known effects of …

Pregnancy is a complex state where changes in maternal physiology have evolved to favor
the development and growth of the placenta and the fetus. These adaptations may affect …

Knowledge of pharmacokinetics and the use of a mechanistic-based approach can improve
our ability to predict the effects of pregnancy for medications when data are limited. Despite …