In response to infection, antigen‐specific CD8+ T cells undergo massive expansion in
numbers, acquire effector mechanisms, and disseminate throughout the body. The …

The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …

CD8+ T cells play a crucial role in controlling intracellular pathogens. The level of memory
CD8+ T cells developing after vaccination or infection influences the degree of T cell …

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …

Highlights•The effector and memory CD8+ T cell populations exhibit significant
heterogeneity.•Effector and memory T cell subsets exist in 'states' and retain some degree of …

Immunological memory is one of the features that define the adaptive immune response: by
generating specific memory cells after infection or vaccination, the host provides itself with a …

The generation of effective adaptive T-cell memory is a cardinal feature of the adaptive
immune system. The establishment of protective T-cell immunity requires the differentiation …

The immune system has evolved by continuously increasing its complexity to provide the
host with an advantage over infectious agents. The development of immunological memory …

In response to infection or effective vaccination, naive antigen‐specific CD8+ T cells
undergo a dramatic highly orchestrated activation process. Initial encounter with an …

CD8+ T cell immunological memory of past antigen exposure can confer long-lived
protection against infections or tumors. The fact that CD8+ memory T cells can have features …