The newly recognized class of 5-hydroxytryptamine receptors (5HT 3) may be involved in
the induction of nausea, since their pharmacological antagonists are effective against …

Ondansetron (GR38032F) is a selective antagonist of 5‐hydroxytryptamine (5‐HT) type 3
receptors. This randomized, doubleblind, cross‐over study was undertaken to evaluate and …

Abstract Antagonists of 5-hydroxytryptamine type 3 (5HT 3) receptors reduce the nausea
induced by cisplatinum, but the effects of these agents on 5HT 3 receptors in the human gut …

SUMMARY Serotonin (5‐hydroxytryptamine; 5‐HT) is found in the enteric nervous system
where it has been implicated in controlling gastrointestinal motor function. A number of …

Objectives To explore the pharmacodynamic effects of the new promotile agent SDZ HTF
919, a selective partial 5‐HT4 receptor agonist, in healthy subjects. Methods A …

We have already reported that 5-hydroxytryptamine3 (5-HT3) receptor antagonists failed to
modify 5-HT-accelerated colonic transit in conscious rats, but the 5-HT3 and 5-HT4 receptor …

The gut is the only organ that can display reflexes and integrative neuronal activity even
when isolated from the central nervous system. This activity can be triggered by luminal …

Methods Animals. Male Sprague-Dawley rats (Charles River Japan Inc., Hino, Japan)
weighing 220 to 330 g and male ddy mice (Japan SLC Inc., Haniamatsu, Japan) weighing …

BACKGROUND Serotonin 5-HT4 receptors are located on enteric cholinergic neurones and
may regulate peristalsis. 5-HT4 receptors on primary afferent neurones have been …

Ondansetron, a potent and highly selective 5-HT3 receptor antagonist, prevents emesis
following chemotherapy by antagonising the action of 5-hydroxytryptamine (5-HT) at 5-HT3 …