The perfusion of canine cardiac muscle with 10 microM oligomycin produced a nearly 90%
slowing of the net rate of tissue ATP depletion from 0.200 to 0.025 mumol X min-1 X g wet wt …

In the present study, isolated dog and rat hearts were perfused in the Langendorff mode with
Krebs bicarbonate buffer in the absence and presence of 10 (-5) M oligomycin. The …

The effect of inhibition of the mitochondrial ATPase with oligomycin on the rate of ATP
depletion and anaerobic glycolysis was studied in the totally ischemic dog heart. An …

Ischemic myocardium was produced by occluding the left circumflex coronary artery in
anesthetized dogs for 10 or 20 min. Autolyzed myocardium was produced by incubating …

Mitochondrial F1F0-ATPase normally synthesizes ATP in the heart, but under ischemic
conditions this enzyme paradoxically causes ATP hydrolysis. Nonselective inhibitors of this …

Cellular ATP levels are determined by the rates of ATP production and ATP hydrolysis. Both
phenomena are affected by ischemia. Mitochondrial enzymes are damaged, inhibiting this …

In the present study we examined factors affecting the reversal of the ischemia-induced
protonic inhibition of the mitochondrial ATPase described earlier (Rouslin, W.(1983) J. Biol …

In the present study we compared the quantitatively most important, Pi-activated
mechanisms for conserving ATP during ischemia in dog and rat cardiac muscle. Earlier …

Twenty minutes of ischemia in canine cardiac muscle produced a 50% to 60% inhibition of
the mitochondrial ATPase. The inhibition has been shown to be triggered by a drop in cell …

It has been hypothesized that, in oxygen-depleted myocardial cells, mitochondria are
depolarized and the F1, F0-proton adenosinetriphosphatase (ATPase) catalyzes net ATP …