Clonally expanded populations of Ig variable gene-mutated B cells are found in the central
nervous system (CNS) of subjects with multiple sclerosis (MS), suggesting the occurrence of …

Analyses have shown that the repertoire of Ig heavy chain sequences (VH) expressed in
multiple sclerosis (MS) plaques or cerebrospinal fluid is consistent with B cell clonal …

Intrathecal oligoclonal bands of the cerebrospinal fluid are considered the most important
immunological biomarkers of multiple sclerosis. They typically consist of clonally expanded …

In multiple sclerosis (MS) pathogenic B cells likely act on both sides of the blood-brain
barrier (BBB). However, it is unclear whether antigen-experienced B cells are shared …

Objective To determine to what extent oligoclonal band (OCB) specificities are clonally
interrelated and to what degree they are associated with corresponding B‐cell responses in …

In multiple sclerosis (MS), lymphocyte—in particular B cell—transit between the central
nervous system (CNS) and periphery may contribute to the maintenance of active disease …

for T-cell help. B-cells internalize and process the antigen–BCR complex, displaying linear
peptides on major histocompatibility complex (MHC) class II. The antigen-primed B-cell …

Fluorescence-activated cell sorting (FACS) analysis of B cell subtypes in 17 CSF samples
from 15 patients with clinically-definite MS revealed that CD19+ B cells accounted for 2 to …

Multiple sclerosis (MS) cerebrospinal fluid and brain contain increased IgG and oligoclonal
bands. Whether this oligoclonal and polyclonal IgG is directed against a disease‐relevant …

We investigated the overlap shared between the immunoglobulin (Ig) proteome of the
cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous …