[HTML][HTML] The role of antibodies in multiple sclerosis
MS Weber, B Hemmer, S Cepok - … Acta (BBA)-Molecular Basis of Disease, 2011 - Elsevier
B cells, plasma cells, and antibodies are commonly found in active central nervous system
(CNS) lesions in patients with multiple sclerosis (MS). B cells isolated from CNS lesions as …
(CNS) lesions in patients with multiple sclerosis (MS). B cells isolated from CNS lesions as …
B cells and multiple sclerosis
D Franciotta, M Salvetti, F Lolli, B Serafini… - The Lancet …, 2008 - thelancet.com
Clonal expansion of B cells and the production of oligoclonal IgG in the brain and
cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) have long been interpreted …
cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) have long been interpreted …
Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross‐react with myelin basic protein and EBV antigen
AG Gabibov, AA Belogurov Jr, YA Lomakin… - The FASEB …, 2011 - Wiley Online Library
Multiple sclerosis (MS) is a widespread neurodegenerative autoimmune disease with
unknown etiology. It is increasingly evident that, together with pathogenic T cells …
unknown etiology. It is increasingly evident that, together with pathogenic T cells …
Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients
JR Rivas, SJ Ireland, R Chkheidze, WH Rounds… - Acta …, 2017 - Springer
Plasmablasts are a highly differentiated, antibody secreting B cell subset whose prevalence
correlates with disease activity in Multiple Sclerosis (MS). For most patients experiencing …
correlates with disease activity in Multiple Sclerosis (MS). For most patients experiencing …
Immunoglobulin G, A, and M—Clonal restriction in multiple sclerosis cerebrospinal fluid and serum—analysis by two-dimensional electrophoresis
MJ Walsh, WW Tourtellotte, J Roman… - Clinical immunology and …, 1985 - Elsevier
Immunoglobulin G, A, and M (IgG, IgA, and IgM) were purified from multiple sclerosis (MS)
cerebrospinal fluid (CSF) and sera and analyzed by two-dimensional electrophoresis. The …
cerebrospinal fluid (CSF) and sera and analyzed by two-dimensional electrophoresis. The …
Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis
RA Williamson, MP Burgoon… - Proceedings of the …, 2001 - National Acad Sciences
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of unknown cause
that afflicts the central nervous system. MS is typified by a highly clonally restricted antigen …
that afflicts the central nervous system. MS is typified by a highly clonally restricted antigen …
Oligoclonality of CD8+ T cells in multiple sclerosis
J Monteiro, R Hingorani, R Peroglizzi, B Apatoff… - …, 1996 - Taylor & Francis
We have shown earlier that CD8+ T cell oligoclonality occurs frequently in normal
individuals and generally exhibits a very diverse repertoire. In order to investigate the role of …
individuals and generally exhibits a very diverse repertoire. In order to investigate the role of …
B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation
E Meinl, M Krumbholz… - Annals of Neurology …, 2006 - Wiley Online Library
B cells have long played an enigmatic role in the scenario of multiple sclerosis
pathogenesis. This review summarizes recent progress in our understanding of B‐cell …
pathogenesis. This review summarizes recent progress in our understanding of B‐cell …
Autoantibodies against central nervous system antigens in a subset of B cell–dominant multiple sclerosis patients
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS), with characteristic inflammatory lesions and demyelination. The clinical benefit of cell …
(CNS), with characteristic inflammatory lesions and demyelination. The clinical benefit of cell …
Common T‐cell receptor Vβ usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis
SJ Lee, KW Wucherpfennig, SA Brod… - Annals of Neurology …, 1991 - Wiley Online Library
T‐cell populations were investigated in the blood and cerebrospinal fluid of patients with
multiple sclerosis and other neurological diseases. Individual T cells were directly cloned …
multiple sclerosis and other neurological diseases. Individual T cells were directly cloned …