Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid are a hallmark of multiple sclerosis
(MS), a disabling inflammatory disease of the central nervous system (CNS). OCBs are …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS).
Microarray‐based global gene expression profiling is a promising method, used to study …

The increasing evidence supporting a role for B cells in the pathogenesis of multiple
sclerosis prompted us to investigate the influence of known susceptibility variants on the …

Using murine monoclonal antibodies to mark total T cells, we have found rapid migration of
T cells into the CSF in progressive multiple sclerosis patients, suggesting that the ongoing …

The study was directed by the coprincipal investigators, KCO, SHK, and VS The
investigation of the MS DN repertoire was initially conceived by VS and JF The overall …

Imbalances in T cell subpopulations have been reported in multiple sclerosis (MS). In the
present study of 31 MS patients, the percentage of T cells with Fc receptors for IgG (TG) was …

We have developed a new technique that allows us to quantify antigen-specific T cells, and
to determine their functional phenotype and origin from naive versus memory populations …

A role of B cells in multiple sclerosis (MS) is well established, but there is limited
understanding of their involvement during active disease. Here, we examined cerebrospinal …

B cells are increasingly regarded as integral to the pathogenesis of multiple sclerosis, in part
as a result of the success of B cell–depletion therapy. Multiple B cell–dependent …

Understanding the pathogenesis of complex immunologic disorders such as multiple
sclerosis (MS) is challenging. Abnormalities in many different cell types are observed in the …