Background Several groups have Observl'CI two distinct yet related phenomena occurring at
the level of the individual patient or rodent strain: restricted V-gene usage and …

Depletion of CD20+ B cells has been related to reduced clinical activity in relapsing–
remitting multiple sclerosis. The underlying mechanism is not understood, because serum …

Our previous results revealed that Igs in lesions and single chain variable fragment Abs
(scFv-Abs) generated from clonal B cells in the cerebrospinal fluid (CSF) from patients with …

Background There is accumulating evidence from immunological, pathological and
therapeutic studies that B cells are key components in the pathophysiology of multiple …

B cells are important in the pathogenesis of multiple sclerosis (MS) and some of the effects
are not dependent on maturation of B cells into immunoglobulin (Ig) producing plasmablasts …

The increased intrathecal production of immunoglobulins within the cerebrospinal fluid
(CSF) compartment commonly observed in multiple sclerosis (MS) implicates participation of …

T cell responses to the immunodominant peptide (residues 83–99) of myelin basic protein
are potentially associated with multiple sclerosis (MS). This study was undertaken to …

B lymphocytes have essential roles in the autoimmune pathogenesis of multiple sclerosis
(MS). They regulate the autoimmune response and participate in the development of the …

The role of B cells in the pathogenesis of Multiple Sclerosis (MS) is incompletely understood.
Here we define a possible role for B cells as myelin-specific antigen presenting cells (B …

The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to
rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their …