Clonal composition and T cell receptor (TCR) repertoire of CD4+ and CD8+ T cells
infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with …

Objective: Intrathecal synthesis of immunoglobulin gamma (IgG) synthesis is frequently
observed in patients with multiple sclerosis (MS). Whereas the extent of intrathecal IgG …

Two or more oligoclonal IgG bands (OB) detected by separation of cerebrospinal fluid (CSF)
proteins while not demonstrable in corresponding serum reflect a local B-cell response …

Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System with
multifocal areas of demyelination. Although its etiology and pathogenesis remain …

Inflammatory diseases of the central nervous system (CNS) are characterized by
cerebrospinal fluid (CSF) pleocytosis often involving the recruitment of B cells. Little is still …

Irrespective of the large body of literature on the putative role of antibodies in the
development of multiple sclerosis (MS), the detection of specific antibody-forming B cells …

B cells have been found to play a critical role in the pathogenesis of several autoimmune
(AI) diseases. A common feature amongst many AI diseases is the formation of ectopic …

Introduction B cells are acknowledged as crucial players in the pathogenesis of multiple
sclerosis (MS). Several disease modifying drugs including cladribine have been shown to …

Meningeal B lymphocyte aggregates have been described in autopsy material of patients
with chronic multiple sclerosis. The presence of meningeal B cell aggregates has been …

The presence of persistent intrathecal oligoclonal immunoglobulin G (IgG) bands (OCBs)
and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease …