When temperature (T) of skin decreases stepwise, cold fibers evoke transient afferent
discharges, inducing cold sensation and heat-gain responses. Hence we have proposed …

Warmth and cold sensations are known to derive from separate warm and cold cutaneous
thermoreceptors in the form of differentiated afferent nerves. The firing rate of warm-sensing …

Transduction in cutaneous cold receptors is poorly understood at present. We have studied
this question using dorsal root ganglion (DRG) neurones in primary culture as a model of the …

Skin temperature is sensed by peripheral thermoreceptors. Using the neuronal soma in
primary culture as a model of the receptor terminal, we have investigated the mechanisms of …

Cold temperature can evoke a wide spectrum of perceptual sensations that range from
freshness to unpleasant cold or overt pain. In mammals, the detection of cold temperature is …

Sensations of cold are mediated by specific thermoreceptor nerve endings excited by low
temperature and menthol. Here we identify a population of cold-sensitive cultured mouse …

Cold sensing in mammals is heterogeneous and more than one type of receptor molecule is
likely to be involved in the transduction process. Most features of innocuous cold receptors …

Afferent neural transmission of temperature sensation from skin thermoreceptors to the
central thermoregulatory system is important for the defense of body temperature against …

Three sub-populations of sensory neurons may be distinguished based on responses to a
decrease in temperature: one has a relatively low threshold for activation (cool fibers), a …

Cold temperature detection involves the process of sensory transduction in cutaneous
primary sensory nerve terminals, which converts thermal stimuli into depolarizations of the …