Assessment of helical interfaces in protein – protein interactions - Molecular BioSystems (RSC
Publishing) DOI:10.1039/B903202A Royal Society of Chemistry View PDF VersionPrevious …

The development of inhibitors for protein–protein interactions frequently involves the mimicry
of secondary structure motifs. While helical protein–protein interactions have been heavily …

Synthetic inhibitors of protein− protein interactions are being discovered despite the inherent
challenge in targeting large contact surfaces with small molecules. An analysis of available …

The modulation of protein–protein interactions (PPIs) by means of creating or stabilizing
secondary structure conformations is a rapidly growing area of research. Recent success in …

Disruption of protein–protein interactions is medicinally important. Interface helices may be
mimicked in helical probes featuring enhanced rigidities, binding to protein targets …

The redesign of protein− protein interactions is a stringent test of our understanding of
molecular recognition and specificity. Previously we engineered a modest specificity switch …

Examination of complexes of proteins with other biomolecules reveals that proteins tend to
interact with partners via folded subdomains, in which the backbone possesses secondary …

Structure-based design of synthetic inhibitors of protein–protein interactions (PPIs) requires
adept molecular design and synthesis strategies as well as knowledge of targetable …

The transient assembly of multiprotein complexes mediates many aspects of cell regulation
and signalling in living organisms. Modulation of the formation of these complexes through …

Protein–protein interactions encompass large surface areas, but often a handful of key
residues dominate the binding energy landscape. Rationally designed small molecule …