The associations between obesity, insulin resistance, and type 2 diabetes mellitus are well
documented. Free fatty acids (FFA), which are often elevated in obesity, have been …

Evidence is reviewed that free fatty acids (FFAs) are one important link between obesity and
insulin resistance and NIDDM. First, plasma FFA levels are elevated in most obese subjects …

Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart,
liver and pancreas. However, chronically elevated plasma FFA appear to have …

Objective To present evidence that free fatty acids (FFA) are an important link between
obesity and insulin resistance. Methods The role of FFA in peripheral insulin resistance …

To investigate the sites of the free fatty acid (FFA) effects to increase basal hepatic glucose
production and to impair hepatic insulin action, we performed 2-h and 7-h Intralipid+ heparin …

Most obese individuals have elevated plasma levels of free fatty acids (FFA) which are
known to cause peripheral (muscle) insulin resistance. They do this by inhibiting insulin …

Free fatty acids (FFA) have been shown to inhibit insulin suppression of endogenous
glucose production (EGP). To determine whether this is the result of stimulation by FFA of …

Plasma free fatty acids (FFA) might mediate the insulin resistance and impaired glucose
tolerance associated with central obesity. Central adipocytes are resistant to insulin …

We have shown previously in humans that insulin partly suppresses hepatic glucose
production (HGP) by an extrahepatic (indirect) mechanism. In the present study, we …

Hepatic insulin resistance and increased endogenous glucose production (EGP) are
associated with increased plasma free fatty acids (FFA). However, the contribution of FFA …