The aim of this study was to investigate the activation of the Wnt/β‐catenin pathway in
osteoarthritis and the role of low‐density lipoprotein receptor‐related protein 5 (LRP5) in …

Introduction Wnt ligands bind to low-density lipoprotein receptor–related protein (LRP) 5 or
6, triggering a cascade of downstream events that include β-catenin signaling. Here we …

The low‐density lipoprotein receptor‐related protein 1 (LRP1) is known as an endocytic and
signal transmission receptor. We formerly reported the gene expression and the localization …

Endochondral ossification is an essential step for skeletal development, which requires
chondrocyte differentiation in growth cartilage. The low-density lipoprotein receptor-related …

Objective. The wingless-type MMTV integration site family (WNT) signalling pathway plays
an important role in embryonic joint and bone development and has been associated with …

Objective Wnt/β-catenin signaling plays an integral and complex role in cartilage
development and maintenance. β-catenin signaling has been linked to osteoarthritis (OA) …

OBJECTIVE: Several genome-wide scans have revealed an osteoarthritis (OA)-susceptibility
locus on chromosome 11q in close proximity to the low-density lipoprotein receptor-related …

Introduction Events normally taking place in the terminal chondrocyte differentiation in the
growth plate are also observed during osteoarthritis (OA) development, suggesting that …

The low density lipoprotein receptor-related protein 5 (LRP5) is a key determinant of bone
mass, via the Wnt signaling pathway control of osteoblast function. This study examined …

Low-density lipoprotein receptor-related protein 1 (LRP1) is known to regulate cell survival
and inflammation. The present study investigated the involvement of LRP1 in the regulation …