Preclinical research has sought to understand the role of the orexin system in cocaine
addiction given the connection between orexin producing cells in the lateral hypothalamus …

Abstract Orexins ('hypocretins') are peptides produced by neurons of the hypothalamus that
project to structures implicated in reward and emotion processing. Converging evidence …

Orexin/hypocretin signaling at the orexin 1 receptor (OX1R) has recently been implicated in
addiction and relapse. We examined the role of the orexin system in cocaine-seeking …

The orexin/hypocretin system has recently been implicated in reward‐processing and
addiction. We examined the involvement of the orexin system in cue‐induced reinstatement …

The orexin/hypocretin system is involved in multiple cocaine addiction processes that
involve drug‐associated environmental cues, including cue‐induced reinstatement of …

The orexin/hypocretin system has been implicated in multiple phases of drug addiction.
Acute orexin receptor blockade with the orexin-1 receptor (OX1R) antagonist, SB-334867 …

Previous studies have shown that female rats exhibit enhanced cocaine seeking during
multiple phases of cocaine addiction compared with males. The orexin/hypocretin system …

Preclinical evidence suggests an important role of the brain orexin system in behaviours
related to drug addiction. This study aimed at assessing the effect of the orexin-1 receptor …

Rationale. Current evidence and literature reviews provide a strong justification for
examining the orexin receptor (OXR) system as a therapeutic target in substance use …

The orexin/hypocretin system is involved in several addiction‐related behaviors. In the
present experiments, we examined the involvement of orexin in heroin reinforcement and …