Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …

Presently, routine screening misses many cases of prediabetes and early type 2 diabetes
(T2D). Therefore, better biomarkers are needed for a simple and early detection of …

OBJECTIVE To conduct a systematic review of cross-sectional and prospective human
studies evaluating metabolite markers identified using high-throughput metabolomics …

The complex aetiology of type 2 diabetes makes effective screening, diagnosis and
prognosis a substantial challenge for the physician. The rapidly developing area of …

Diabetes represents one of the most important global health problems because it is
associated with a large economic burden for the health systems of many countries. Whereas …

Improvements in metabolite-profiling techniques are providing increased breadth of
coverage of the human metabolome and may highlight biomarkers and pathways in …

Aims/hypothesis Metabolomic profiling offers the potential to reveal metabolic pathways
relevant to the pathophysiology of diabetes and improve diabetes risk prediction. Methods …

Using a nontargeted metabolomics approach of 447 fasting plasma metabolites, we
searched for novel molecular markers that arise before and after hyperglycemia in a large …

The perturbation in plasma free amino acid metabolome has been observed previously in
diabetes mellitus, and is associated with insulin resistance as well as the onset of …

Amino acids have emerged as novel biomarkers for predicting type 2 diabetes (T2D), but the
epidemiologic data linking circulating amino acid profiles with T2D are sparse in Asian …