The existence of acylethanolamides (AEs) in the mammalian brain has been known for
decades. Among AEs, palmitoylethanolamide (PEA) is abundant in the central nervous …

Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its
neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the N …

Highlights•PEA is an anti-inflammatory and neuroprotective compound.•Pharmacological
tools are available to control PEA levels via FAAH and NAAA inhibition.•FAAH and NAAA …

Glia are key players in a number of nervous system disorders. Besides releasing glial and
neuronal signaling molecules directed to cellular homeostasis, glia respond also to pro …

Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this
compound is naturally produced in many plant and animal food sources, as well as in cells …

The growth of knowledge about the molecular mechanisms underlying Alzheimer's disease
(AD) has highlighted the role of neuroinflammation in the pathophysiology of this disorder …

Increasing evidence strongly supports the key role of neuroinflammation in the
pathophysiology of neurodegenerative diseases, such as Alzheimer's disease …

Neuroinflammation is a physiological response aimed at maintaining the homodynamic
balance and providing the body with the fundamental resource of adaptation to endogenous …

Inflammation is fundamentally a protective cellular response aimed at removing injurious
stimuli and initiating the healing process. However, when prolonged, it can override the …

The role of palmitoylethanolamide (PEA) in the regulation of complex systems involved in
the inflammatory response, pruritus, neurogenic and neuropathic pain is well understood …