Some 30–50% of the global population and almost 20% of the European population actually
suffer from chronic pain, which presents a tremendous burden to society when this pain …

The use of a complete nutritional approach seems increasingly promising to combat chronic
inflammation. The choice of healthy sources of carbohydrates, fats, and proteins, associated …

Alzheimer's disease (AD) is a neurodegenerative disorder responsible for the majority of
dementia cases in elderly people. It is widely accepted that the main hallmarks of AD are not …

The endogenous fatty acid palmitoylethanolamide (PEA) is one of the members of N-acyl-
ethanolamines family. PEA was identified more than five decades ago and was shown to …

Alzheimer disease (AD) is the most common form of neurodegenerative dementia. Amyloid-
β deposition, neurofibrillary tangle formation, and neuro-inflammation are the major …

Despite the clear roles played by peroxisome proliferators-activated receptor α (PPAR-α) in
lipid metabolism, inflammation and feeding, the effects of its activation in the central nervous …

High-fat diet (HFD) consumption leads to obesity and a chronic state of low-grade
inflammation, named metainflammation. Notably, metainflammation contributes to …

Microglial cell activation and migration play an important role in neuroinflammation
propagation. While it is known that the lipid transmitter palmitoylethanolamide (PEA) …

Persistent pain affects nearly half of all people seeking medical care in the US alone, and
accounts for at least $80 billion worth of lost productivity each year. Among all types of …

Nicotine stimulates the activity of mesolimbic dopamine neurons, which is believed to
mediate the rewarding and addictive properties of tobacco use. Accumulating evidence …