The antidepressant effect of a compound formed by co-ultramicronized
palmitoylethanolamide (PEA) and luteolin (PEA+ luteolin) was investigated in a mouse …

The discovery of anandamide as an endogenous ligand for the cannabinoid receptors has
led to a resurgence of interest in the fatty acid amides. However, N-palmitoylethanolamine …

Palmitoylethanolamide (PEA), the naturally occurring amide of palmitic acid and
ethanolamine, reduces pain and inflammation through an as-yet-uncharacterized …

Fatty acid ethanolamides such as palmitoylethanolamide (PEA) and oleoylethanolamide
(OEA) are lipid-derived mediators that potently inhibit pain and inflammation by ligating type …

Focal cerebral ischemia (FCI) induces rapid neuronal death in the ischemic core, which
gradually expands toward the penumbra, partly as the result of a neuroinflammatory …

Palmitoylethanolamide (PEA) has been suggested to have useful analgesic properties and
to be devoid of unwanted effects. Here, we have examined critically this contention, and …

The endogenous cannabimimetic compound, and anandamide analogue, N-palmitoyl-
ethanolamine (PEA), was shown to exert potent anti-inflammatory and analgesic effects in …

N-palmitoylethanolamine (PEA), an endogenous fatty acid ethanolamide, plays a key role in
the regulation of the inflammatory response and pain through, among others, activation of …

Persistent pain in neuropathic conditions is often quite refractory to conventional analgesic
therapy, with most patients obtaining, at best, only partial relief of symptoms. The tendency …

Background The fatty acid amide palmitoylethanolamide (PEA) has been studied
extensively for its anti-inflammatory and neuroprotective actions. The lipidic nature and large …