Ferroptosis and musculoskeletal diseases:“Iron Maiden” cell death may be a promising therapeutic target

Y Zhang, X Huang, B Qi, C Sun, K Sun, N Liu… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis is a novel form of cell death precisely regulated by iron metabolism, antioxidant
processes, and lipid metabolism that plays an irreplaceable role in the development of many …

Iron and ferroptosis: A still ill‐defined liaison

S Doll, M Conrad - IUBMB life, 2017 - Wiley Online Library
Ferroptosis is a recently described form of regulated necrotic cell death, which appears to
contribute to a number of diseases, such as tissue ischemia/reperfusion injury, acute renal …

Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

L Zeng, K Yang, G Yu, W Hao, X Zhu, A Ge… - Cell Death & …, 2024 - nature.com
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis
remain unclear. Currently, increasing research has highlighted the role of ferroptosis in …

Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases

J Fan, T Jiang, D He - Frontiers in Immunology, 2023 - frontiersin.org
Ferroptosis, a novel type of regulated cell death mediated by iron-dependent lipid oxidation,
was discovered a decade ago. Significant progress has been made in our knowledge of …

[HTML][HTML] STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice

M Zhu, L Peng, S Huo, D Peng, J Gou, W Shi… - Free Radical Biology …, 2023 - Elsevier
High-fat diet (HFD) intake provokes obesity and cardiac anomalies. Recent studies have
found that ferroptosis plays a role in HFD-induced cardiac injury, but the underlying …

Ferroptosis and autoimmune diseases

B Lai, CH Wu, CY Wu, SF Luo, JH Lai - Frontiers in Immunology, 2022 - frontiersin.org
Adequate control of autoimmune diseases with an unclear etiology resulting from
autoreactivation of the immune system remains a major challenge. One of the factors that …

Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes

G Du, Q Zhang, X Huang, Y Wang - Frontiers in Genetics, 2022 - frontiersin.org
Ferroptosis is an iron-dependent programmed cell death, which is different from apoptosis,
necrosis, and autophagy. Specifically, under the action of divalent iron or ester oxygenase …

Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities

R Miao, X Fang, Y Zhang, J Wei, Y Zhang… - Cell Death & Disease, 2023 - nature.com
The maintenance of iron homeostasis is essential for proper endocrine function. A growing
body of evidence suggests that iron imbalance is a key factor in the development of several …

Ferroptosis and its role in skeletal muscle diseases

Y Wang, Z Zhang, W Jiao, Y Wang, X Wang… - Frontiers in molecular …, 2022 - frontiersin.org
Ferroptosis is characterized by the accumulation of iron and lipid peroxidation products,
which regulates physiological and pathological processes in numerous organs and tissues …

[HTML][HTML] The role of ferroptosis in metabolic diseases

L Xie, B Fang, C Zhang - Biochimica et Biophysica Acta (BBA)-molecular …, 2023 - Elsevier
The annual incidence of metabolic diseases such as diabetes, non-alcoholic fatty liver
disease (NAFLD), osteoporosis, and atherosclerosis (AS) is increasing, resulting in a heavy …