Posttranslational modifications in ferroptosis

X Wei, X Yi, XH Zhu, DS Jiang - Oxidative medicine and …, 2020 - Wiley Online Library
Ferroptosis was first coined in 2012 to describe the form of regulated cell death (RCD)
characterized by iron‐dependent lipid peroxidation. To date, ferroptosis has been implicated …

Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes

G Du, Q Zhang, X Huang, Y Wang - Frontiers in Genetics, 2022 - frontiersin.org
Ferroptosis is an iron-dependent programmed cell death, which is different from apoptosis,
necrosis, and autophagy. Specifically, under the action of divalent iron or ester oxygenase …

Ferroptosis by lipid peroxidation: the tip of the iceberg?

X Chen, R Kang, D Tang - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Ferroptosis is a type of regulated necrosis mainly caused by iron-mediated lipid peroxidation
(Tang and Kroemer, 2020). Ferroptosis dysfunction is implicated in various diseases …

Ferroptosis and its role in skeletal muscle diseases

Y Wang, Z Zhang, W Jiao, Y Wang, X Wang… - Frontiers in molecular …, 2022 - frontiersin.org
Ferroptosis is characterized by the accumulation of iron and lipid peroxidation products,
which regulates physiological and pathological processes in numerous organs and tissues …

Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities

R Miao, X Fang, Y Zhang, J Wei, Y Zhang… - Cell Death & Disease, 2023 - nature.com
The maintenance of iron homeostasis is essential for proper endocrine function. A growing
body of evidence suggests that iron imbalance is a key factor in the development of several …

An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis

JW Kim, JY Lee, M Oh, EW Lee - Experimental & Molecular Medicine, 2023 - nature.com
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid
peroxidation. This process contributes to cellular and tissue damage in various human …

Ferroptosis: A potential target for the intervention of intervertebral disc degeneration

LP Zhou, RJ Zhang, CY Jia, L Kang… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis, an iron-dependent form of programmed cell death marked by phospholipid
peroxidation, is regulated by complex cellular metabolic pathways including lipid …

[HTML][HTML] Protective effects of ferroptosis inhibition on high fat diet-induced liver and renal injury in mice

Y Luo, H Chen, H Liu, W Jia, J Yan, W Ding… - … Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
As a complex and highly prevalent global public health problem, obesity is associated with
multiple diseases, including liver and renal injury. As an iron-dependent form of cell death …

Ferroptosis: molecular mechanisms and health implications

D Tang, X Chen, R Kang, G Kroemer - Cell research, 2021 - nature.com
Cell death can be executed through different subroutines. Since the description of
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …

[PDF][PDF] Ferroptosis: principles and significance in health and disease

F Chen, R Kang, D Tang, J Liu - Journal of Hematology & Oncology, 2024 - Springer
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid
peroxidation, is governed by molecular networks involving diverse molecules and …