[HTML][HTML] The molecular mechanisms of ferroptosis and its role in cardiovascular disease

Y Zhang, L Xin, M Xiang, C Shang, Y Wang… - Biomedicine & …, 2022 - Elsevier
Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of
lipid peroxides (LOOH) and redox disequilibrium. Ferroptosis shows unique characteristics …

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

BR Stockwell - Cell, 2022 - cell.com
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Ferroptosis: a new strategy for cardiovascular disease

Y Wang, J Wu - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Cardiovascular disease (CVD) is currently one of the prevalent causes of human death. Iron
is one of the essential trace elements in the human body and a vital component of living …

[HTML][HTML] The mechanisms of ferroptosis and its role in atherosclerosis

X Xu, XD Xu, MQ Ma, Y Liang, YB Cai, ZX Zhu… - Biomedicine & …, 2024 - Elsevier
Ferroptosis is a newly identified form of non-apoptotic programmed cell death, characterized
by the iron-dependent accumulation of lethal lipid reactive oxygen species (ROS) and …

Dynamic regulation of ferroptosis by lipid metabolism

N Naowarojna, TW Wu, Z Pan, M Li… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Ferroptosis is featured by the accumulation of polyunsaturated-lipid
peroxidation on cellular membranes in an iron-dependent manner. Ferroptosis has been …

Ferroptosis as a novel therapeutic target for diabetes and its complications

XD Yang, YY Yang - Frontiers in Endocrinology, 2022 - frontiersin.org
The global diabetes epidemic and its complications are increasing, thereby posing a major
threat to public health. A comprehensive understanding of diabetes mellitus (DM) and its …

Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis

Q Zhang, H Qu, Y Chen, X Luo, C Chen… - Frontiers in Cell and …, 2022 - frontiersin.org
As one of the cornerstones of clinical cardiovascular disease treatment, statins have an
extensive range of applications. However, statins commonly used have side reactions …

Double-edge sword roles of iron in driving energy production versus instigating ferroptosis

S Zhang, W Xin, GJ Anderson, R Li, L Gao… - Cell Death & …, 2022 - nature.com
Iron is vital for many physiological functions, including energy production, and dysregulated
iron homeostasis underlies a number of pathologies. Ferroptosis is a recently recognized …

Ferroptosis: A new regulatory mechanism in neuropathic pain

L Li, L Guo, R Gao, M Yao, X Qu, G Sun… - Frontiers in aging …, 2023 - frontiersin.org
Neuropathic pain (NP) is pain caused by damage to the somatosensory system. It is a
common progressive neurodegenerative disease that usually presents with clinical features …

Implication of ferroptosis in aging

M Mazhar, AU Din, H Ali, G Yang, W Ren, L Wang… - Cell Death …, 2021 - nature.com
Life is indeed continuously going through the irreversible and inevitable process of aging.
The rate of aging process depends on various factors and varies individually. These factors …