Oncolytic virotherapy is a type of nanomedicine with a dual antitumor mechanism. Viruses
are engineered to selectively infect and lyse cancer cells directly, leading to the release of …

Therapeutic oncolytic viruses (virotherapeutics) constitute a novel class of targeted
anticancer agents that have unique mechanisms of action compared with other cancer …

Viruses as cancer therapies have attracted attention since the 19th century. Scientists
observation that viruses can preferentially lyse cancer cells rather than healthy cells, created …

Conditional replicative, oncolytic adenoviruses are genetically modified to replicate primarily
in malignant cells with oncogenetic defects, selectively killing cancer cells in the process …

Viral oncolytic therapy is under intense investigation as a novel anticancer strategy. Both
alone and in combination with other conventional treatment modalities, viral oncolytics …

Recent years have seen rapid advances in the preclinical development and clinical
evaluation of oncolytic (cancer-lysing) virus-based therapies, and these are emerging as …

Therapeutic oncolytic viruses: clinical advances and future... : Current Opinion in Oncology
Therapeutic oncolytic viruses: clinical advances and future directions : Current Opinion in …

Viruses can be engineered or adapted for selective propagation in neoplastic tissues and
further modified for therapeutic transgene expression to enhance their antitumor potency …

Tumor-selective replicating viruses offer appealing advantages over conventional cancer
therapy and are a promising new approach for the treatment of human cancer. The …

The field of oncolytic virotherapy has seen remarkable advancements in last two decades,
leading to approval of the first oncolytic immuno-virotherapy, Talimogene Laherparepvec, for …