Skipping adolescence to become super-inflammatory monocytes
Single-cell RNA-sequencing of myeloid cells during neuroinflammation identifies a new
population of pathogenic Cxcl10-expressing phagocytes, which develop independently of …
population of pathogenic Cxcl10-expressing phagocytes, which develop independently of …
IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation
A Amorim, D De Feo, E Friebel, F Ingelfinger… - Nature …, 2022 - nature.com
Abstract During inflammation, Ly6Chi monocytes are rapidly mobilized from the bone
marrow (BM) and are recruited into inflamed tissues, where they undergo monocyte-to …
marrow (BM) and are recruited into inflamed tissues, where they undergo monocyte-to …
Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation
Multiple sclerosis (MS) is characterized by pathological inflammation that results from the
recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to …
recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to …
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation
Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …
Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants
In spite of their precipitous encounter with the environment, newborn infants cannot readily
mount T helper type 1 (TH1) cell antibacterial and antiviral responses. Instead, they show …
mount T helper type 1 (TH1) cell antibacterial and antiviral responses. Instead, they show …
Signals for HSC emergence
I Visan - Nature Immunology, 2015 - nature.com
After being activated, microglia in the central nervous system (CNS) fail to acquire an anti-
inflammatory phenotype, and bone marrow–derived monocytes must be recruited for …
inflammatory phenotype, and bone marrow–derived monocytes must be recruited for …
Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
IL King, TL Dickendesher… - Blood, The Journal of the …, 2009 - ashpublications.org
Mature myeloid cells (macrophages and CD11b+ dendritic cells) form a prominent
component of neuroinflammatory infiltrates in multiple sclerosis and experimental …
component of neuroinflammatory infiltrates in multiple sclerosis and experimental …
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
MJC Jordão, R Sankowski, SM Brendecke, Sagar… - Science, 2019 - science.org
INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …
Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke
Monocyte-derived and tissue-resident macrophages are ontogenetically distinct
components of the innate immune system. Assessment of their respective functions in …
components of the innate immune system. Assessment of their respective functions in …
Monocyte-like and mature macrophages produce CXCL13 (B cell–attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis
HS Carlsen, ES Baekkevold, HC Morton, G Haraldsen… - Blood, 2004 - ashpublications.org
The homeostatic chemokine CXCL13 (also called B cell-attracting chemokine 1 [BCA-1] or B-
lymphocyte chemoattractant [BLC]) is constitutively expressed in secondary lymphoid tissue …
lymphocyte chemoattractant [BLC]) is constitutively expressed in secondary lymphoid tissue …