Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis
(MS) that shares many features with the human disease. This review will focus on the role of …

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune demyelinating diseases of the central nervous system (CNS) …

Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous
system (CNS), which involves autoimmune responses to myelin antigens. Studies in …

IL-17–producing CD8+ T (Tc17) cells are detectible in multiple sclerosis (MS) lesions;
however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we …

Interleukin‐17 (IL‐17) induces the production of granulocyte colony‐stimulating factor (G‐
CSF) and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an …

The discovery of the T helper (Th) 17 lineage, involved in the protection against fungal and
extracellular bacterial infections, has profoundly revolutionized our current understanding of …

Abstract T helper 17 (Th17), a distinct subset of CD4+ T cells with IL-17 as their major
cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases …

Our understanding of the role of T cells in human disease is undergoing revision as a result
of the discovery of T‐helper 17 (Th17) cells, a unique CD4+ T‐cell subset characterized by …

Until recently, autoimmune diseases had been categorized as either Th1-or Th2-mediated
diseases. However, the discovery of a novel subset of helper T cells producing interleukin …

Naïve T cells are multipotential precursors that differentiate into various effector subsets,
such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct …