Formulating amorphous solid dispersions (ASDs) is one of the most promising strategies to
overcome solubility limitations in drug development. In this work, development of nimesulide …

Designing and preparing amorphous solid dispersion (ASD) nanoparticles of poorly water-
soluble active pharmaceutical ingredients is an efficient formulation approach to overcome …

The purpose of this preliminary study was to investigate the physico-chemical properties of
nimesulide precipitated by continuous supercritical antisolvent (SAS) from different organic …

The purpose of the present study was to fabricate ezetimibe-hydroxypropyl cellulose (HPC)
solid dispersion nanoparticles with enhanced dissolution and oral bioavailability using the …

The study was designed to investigate the feasibility of supercritical carbon dioxide (scCO2)
processing for the preparation of simvastatin (SIM) solid dispersions (SDs) in …

Poor water solubility and poor bioavailability are problems with many pharmaceuticals.
Increasing surface area by micronization is an effective strategy to overcome these …

The low aqueous solubility and subsequently slow dissolution rate, as well as the poor
bioavailability of several active pharmaceutical ingredients (APIs), are major challenges in …

The aim of this work is to investigate the feasibility of using supercritical anti-solvent (SAS)
co-precipitation process to influence the crystallinity or amorphous character of a crystalline …

Microparticles of a poorly water-soluble model drug, nevirapine (NEV) were prepared by
supercritical antisolvent (SAS) method and simultaneously deposited on the surface of …

In this study, supercritical fluid (SCF) technology was applied to prepare reliable solid
dispersions of pharmaceutical compounds with limited bioavailability using ibuprofen (IBU) …