In silico designed RNA aptamer against epithelial cell adhesion molecule for cancer cell imaging

R Bavi, Z Liu, Z Han, H Zhang, Y Gu - Biochemical and biophysical …, 2019 - Elsevier
Aptamers are short, single-stranded oligonucleotides that bind to their targets with high
affinity and specificity. Usually, aptamers are selected experimentally using SELEX …

In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers

DR Bell, JK Weber, W Yin, T Huynh… - Proceedings of the …, 2020 - National Acad Sciences
Nucleic acid aptamers hold great promise for therapeutic applications due to their favorable
intrinsic properties, as well as high-throughput experimental selection techniques. Despite …

RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule

S Shigdar, J Lin, Y Yu, M Pastuovic, M Wei… - Cancer …, 2011 - Wiley Online Library
The lack of a specific targeting strategy against cancer stem cells in current cancer treatment
regimens is at least partly responsible for life‐threatening cytotoxicity for patients undergoing …

[HTML][HTML] Selection and targeting of EpCAM protein by ssDNA aptamer

W Alshaer, N Ababneh, M Hatmal, H Izmirli… - PLoS …, 2017 - journals.plos.org
Aptamers are molecules that reveal highly complex and refined molecular recognition
properties. These molecules are capable of binding with high affinity and selectivity to …

[HTML][HTML] Design and prediction of aptamers assisted by in silico methods

SJ Lee, J Cho, BH Lee, D Hwang, JW Park - Biomedicines, 2023 - mdpi.com
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …

[HTML][HTML] Novel design of RNA aptamers as cancer inhibitors and diagnosis targeting the tyrosine kinase domain of the nt-3 growth factor receptor using a …

AM Muhammad, A Zari, NH Alsubhi, MH Al-Zahrani… - Molecules, 2022 - mdpi.com
Aptamers, the nucleic acid analogs of antibodies, bind to their target molecules with
remarkable specificity and sensitivity, making them promising diagnostic and therapeutic …

In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets

A Escamilla-Gutiérrez, RM Ribas-Aparicio… - … nucleotides & nucleic …, 2021 - Taylor & Francis
RNA aptamers are single-stranded nucleic acids of 20–100 nucleotides, with high sensitivity
and specificity against particular molecular targets. In vitro production and selection of …

[HTML][HTML] The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer

D Morozov, V Mironov, RV Moryachkov… - … Therapy-Nucleic Acids, 2021 - cell.com
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as
synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer …

[HTML][HTML] In silico post-SELEX screening and experimental characterizations for acquisition of high affinity DNA aptamers against carcinoembryonic antigen

QL Wang, HF Cui, JF Du, QY Lv, X Song - RSC advances, 2019 - pubs.rsc.org
DNA aptamers against carcinoembryonic antigen (CEA) have been identified through the
systematic evolution of ligands by exponential enrichment (SELEX) technique, but their …

Selection and characterization of novel DNA aptamer against colorectal carcinoma Caco‐2 cells

Y Maimaitiyiming, C Yang, Y Wang… - Biotechnology and …, 2019 - Wiley Online Library
Aptamers are short, single‐stranded nucleic acid (DNA or RNA) oligonucleotides that can be
obtained by a technique called systematic evolution of ligands by exponential enrichment …