In silico designed RNA aptamer against epithelial cell adhesion molecule for cancer cell imaging
R Bavi, Z Liu, Z Han, H Zhang, Y Gu - Biochemical and biophysical …, 2019 - Elsevier
Aptamers are short, single-stranded oligonucleotides that bind to their targets with high
affinity and specificity. Usually, aptamers are selected experimentally using SELEX …
affinity and specificity. Usually, aptamers are selected experimentally using SELEX …
In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers
Nucleic acid aptamers hold great promise for therapeutic applications due to their favorable
intrinsic properties, as well as high-throughput experimental selection techniques. Despite …
intrinsic properties, as well as high-throughput experimental selection techniques. Despite …
RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule
The lack of a specific targeting strategy against cancer stem cells in current cancer treatment
regimens is at least partly responsible for life‐threatening cytotoxicity for patients undergoing …
regimens is at least partly responsible for life‐threatening cytotoxicity for patients undergoing …
[HTML][HTML] Selection and targeting of EpCAM protein by ssDNA aptamer
Aptamers are molecules that reveal highly complex and refined molecular recognition
properties. These molecules are capable of binding with high affinity and selectivity to …
properties. These molecules are capable of binding with high affinity and selectivity to …
[HTML][HTML] Design and prediction of aptamers assisted by in silico methods
SJ Lee, J Cho, BH Lee, D Hwang, JW Park - Biomedicines, 2023 - mdpi.com
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
[HTML][HTML] Novel design of RNA aptamers as cancer inhibitors and diagnosis targeting the tyrosine kinase domain of the nt-3 growth factor receptor using a …
Aptamers, the nucleic acid analogs of antibodies, bind to their target molecules with
remarkable specificity and sensitivity, making them promising diagnostic and therapeutic …
remarkable specificity and sensitivity, making them promising diagnostic and therapeutic …
In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets
A Escamilla-Gutiérrez, RM Ribas-Aparicio… - … nucleotides & nucleic …, 2021 - Taylor & Francis
RNA aptamers are single-stranded nucleic acids of 20–100 nucleotides, with high sensitivity
and specificity against particular molecular targets. In vitro production and selection of …
and specificity against particular molecular targets. In vitro production and selection of …
[HTML][HTML] The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as
synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer …
synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer …
[HTML][HTML] In silico post-SELEX screening and experimental characterizations for acquisition of high affinity DNA aptamers against carcinoembryonic antigen
QL Wang, HF Cui, JF Du, QY Lv, X Song - RSC advances, 2019 - pubs.rsc.org
DNA aptamers against carcinoembryonic antigen (CEA) have been identified through the
systematic evolution of ligands by exponential enrichment (SELEX) technique, but their …
systematic evolution of ligands by exponential enrichment (SELEX) technique, but their …
Selection and characterization of novel DNA aptamer against colorectal carcinoma Caco‐2 cells
Y Maimaitiyiming, C Yang, Y Wang… - Biotechnology and …, 2019 - Wiley Online Library
Aptamers are short, single‐stranded nucleic acid (DNA or RNA) oligonucleotides that can be
obtained by a technique called systematic evolution of ligands by exponential enrichment …
obtained by a technique called systematic evolution of ligands by exponential enrichment …