Highlights•Musculoskeletal disease treatments are restricted mainly to symptom relief.•Stem
cell therapy can offer long-lasting effective treatment.•Innate properties of MSCs make them …

Degenerative musculoskeletal diseases (DMDs), including osteoporosis, osteoarthritis,
degenerative disc disease, and sarcopenia, present major challenges in the aging …

The interest on applying mesenchymal stromal cells (MSCs) in orthopedic disorders has
risen tremendously in the last years due to scientific successes in preclinical in vitro and …

Musculoskeletal disorders constitute a substantial disease burden. Neither conservative
management nor surgical intervention provides adequate treatment for several pathologies …

The use of stem cells in orthopedics has been researched for many years, with robust
animal data that show efficacy in cartilage healing, tendon repair, and intervertebral disk …

Despite decades of research, remaining safety concerns regarding disease transmission,
heterotopic tissue formation, and tumorigenicity have kept stem cell‐based therapies largely …

Background The use of mesenchymal stem cells (MSCs) in clinical applications for the
treatment of musculoskeletal disease is steadily increasing in office-based practice. The so …

Regenerative therapies in the musculoskeletal system are based on the suitable application
of cells, biomaterials, and/or factors. For an effective approach, numerous aspects have to …

Skeletal stem cells (SSCs) were originally discovered in the bone marrow stroma. They are
capable of self-renewal and multilineage differentiation into osteoblasts, chondrocytes …

Human bone marrow-derived mesenchymal stem cells (MSCs) can self-renew and
differentiate into osteoblasts, chondrocytes, and adipocytes. MSCs have effectively emerged …