Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading
L Gao, G Liu, X Wu, C Liu, Y Wang, M Ma, Y Ma… - Archives of Biochemistry …, 2023 - Elsevier
Autophagy is an important mechanosensitive response for cellular homeostasis and survival
in osteocytes. However, the mechanism and its effect on bone metabolism have not yet …
in osteocytes. However, the mechanism and its effect on bone metabolism have not yet …
[HTML][HTML] Mechanically induced autophagy is associated with ATP metabolism and cellular viability in osteocytes in vitro
Both mechanical loading and intracellular autophagy play important roles in bone
homeostasis; however, their relationship remains largely unexplored. The objectives of this …
homeostasis; however, their relationship remains largely unexplored. The objectives of this …
Osteocytes promote osteoclastogenesis via autophagy-mediated RANKL secretion under mechanical compressive force
W Li, J Zhao, W Sun, H Wang, Y Pan, L Wang… - Archives of Biochemistry …, 2020 - Elsevier
Osteocytes sense extracellular mechanical stimuli and transduce them into biochemical
signals to regulate bone remodeling. The function is also evidenced in orthodontic tooth …
signals to regulate bone remodeling. The function is also evidenced in orthodontic tooth …
Autophagy in bone remodeling: a regulator of oxidative stress
C Zhu, S Shen, S Zhang, M Huang, L Zhang… - Frontiers in …, 2022 - frontiersin.org
Bone homeostasis involves bone formation and bone resorption, which are processes that
maintain skeletal health. Oxidative stress is an independent risk factor, causing the …
maintain skeletal health. Oxidative stress is an independent risk factor, causing the …
Autophagy activation facilitates mechanical stimulation-promoted osteoblast differentiation and ameliorates hindlimb unloading-induced bone loss
Z Zhou, G Shi, X Zheng, S Jiang, L Jiang - Biochemical and biophysical …, 2018 - Elsevier
Autophagy has been indicated to be involved in regulating bone metabolism. However, little
is known about the role of autophagy in mechanical stimulation-influenced osteoblast …
is known about the role of autophagy in mechanical stimulation-influenced osteoblast …
Glucocorticoids enhanced osteoclast autophagy through the PI3K/Akt/mTOR signaling pathway
L Fu, W Wu, X Sun, P Zhang - Calcified tissue international, 2020 - Springer
Autophagy is an evolutionarily conserved dynamic process and present in variety of cells at
basal levels to maintain homeostasis and to promote cell survival in response to stresses …
basal levels to maintain homeostasis and to promote cell survival in response to stresses …
The role of autophagy in osteoclast differentiation and bone resorption function
A Montaseri, C Giampietri, M Rossi, A Riccioli… - Biomolecules, 2020 - mdpi.com
Autophagy is an evolutionary conserved and highly regulated recycling process of cellular
wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic …
wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic …
Autophagy relieves the function inhibition and apoptosis‑promoting effects on osteoblast induced by glucocorticoid
Y Han, L Zhang, Y Xing, L Zhang… - International …, 2018 - spandidos-publications.com
Autophagy may be a major mechanism by which osteoblasts (OBs) protect against the
negative effects of chronic glucocorticoid (GC) usage. OBs are closely associated with the …
negative effects of chronic glucocorticoid (GC) usage. OBs are closely associated with the …
High glucose downregulates the effects of autophagy on osteoclastogenesis via the AMPK/mTOR/ULK1 pathway
Z Cai, B Yang, Y Shi, W Zhang, F Liu, W Zhao… - Biochemical and …, 2018 - Elsevier
Diabetes is a chronic disease that disrupts the balance between bone formation and bone
desorption, which can lead to osteoporosis, increasing the risk of fracture. However …
desorption, which can lead to osteoporosis, increasing the risk of fracture. However …
Autophagy in osteoblasts is involved in mineralization and bone homeostasis
M Nollet, S Santucci-Darmanin, V Breuil… - Autophagy, 2014 - Taylor & Francis
Bone remodeling is a tightly controlled mechanism in which osteoblasts (OB), the cells
responsible for bone formation, osteoclasts (OC), the cells specialized for bone resorption …
responsible for bone formation, osteoclasts (OC), the cells specialized for bone resorption …