CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance

M Abavisani, R Khayami, M Hoseinzadeh… - Drug Resistance …, 2023 - Elsevier
The phenomenon of antibiotic resistance (AR) and its increasing global trends and
destructive waves concerns patients and the healthcare system. In order to combat AR, it is …

The application of the CRISPR-Cas system in antibiotic resistance

S Tao, H Chen, N Li, W Liang - Infection and drug resistance, 2022 - Taylor & Francis
The emergence and global epidemic of antimicrobial resistance (AMR) poses a serious
threat to global public health in recent years. AMR genes are shared between bacterial …

[HTML][HTML] Harnessing the CRISPR-Cas systems to combat antimicrobial resistance

C Duan, H Cao, LH Zhang, Z Xu - Frontiers in Microbiology, 2021 - frontiersin.org
The emergence of antimicrobial-resistant (AMR) bacteria has become one of the most
serious threats to global health, necessitating the development of novel antimicrobial …

How CRISPR-Cas system could be used to combat antimicrobial resistance

P Gholizadeh, Ş Köse, S Dao, K Ganbarov… - Infection and drug …, 2020 - Taylor & Francis
Rapid emergence of antibiotic-resistant bacteria has made it harder for us to combat
infectious diseases and to develop new antibiotics. The clustered regularly interspaced short …

CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance

A Mayorga-Ramos, J Zúñiga-Miranda… - ACS Infectious …, 2023 - ACS Publications
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …

[HTML][HTML] CRISPR-Cas system: a potential alternative tool to cope antibiotic resistance

B Aslam, M Rasool, A Idris, S Muzammil, RF Alvi… - … Resistance & Infection …, 2020 - Springer
Antibiotic exposure leads to massive selective pressures that initiate the emergence and
spread of antibiotic resistance in commensal and pathogenic bacteria. The slow process of …

[HTML][HTML] CRISPR-cas system: biological function in microbes and its use to treat antimicrobial resistant pathogens

MAB Shabbir, MZ Shabbir, Q Wu, S Mahmood… - Annals of clinical …, 2019 - Springer
The development of antibiotic resistance in bacteria is a major public health threat. Infection
rates of resistant pathogens continue to rise against nearly all antimicrobials, which has led …

[HTML][HTML] Engineered CRISPR-Cas systems for the detection and control of antibiotic-resistant infections

Y Wu, D Battalapalli, MJ Hakeem, V Selamneni… - Journal of …, 2021 - Springer
Antibiotic resistance is spreading rapidly around the world and seriously impeding efforts to
control microbial infections. Although nucleic acid testing is widely deployed for the …

[HTML][HTML] CRISPR-Cas system: a tool to eliminate drug-resistant gram-negative bacteria

R Kundar, K Gokarn - Pharmaceuticals, 2022 - mdpi.com
Rapidly emerging drug-resistant superbugs, especially Gram-negative bacteria, pose a
serious threat to healthcare systems all over the globe. Newer strategies are being …

CRISPR-based antibacterials: transforming bacterial defense into offense

AC Greene - Trends in biotechnology, 2018 - cell.com
The development of antimicrobial-resistant (AMR) bacteria poses a serious worldwide
health concern. CRISPR-based antibacterials are a novel and adaptable method for …