[HTML][HTML] Role of amino acid transporters in amino acid sensing
PM Taylor - The American journal of clinical nutrition, 2014 - Elsevier
Amino acid (AA) transporters may act as sensors, as well as carriers, of tissue nutrient
supplies. This review considers recent advances in our understanding of the AA-sensing …
supplies. This review considers recent advances in our understanding of the AA-sensing …
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
Abstract The Tricarboxylic Acid (TCA) Cycle is arguably the most critical metabolic cycle in
physiology and exists as an essential interface coordinating cellular metabolism …
physiology and exists as an essential interface coordinating cellular metabolism …
Role of GCN2-independent signaling through a noncanonical PERK/NRF2 pathway in the physiological responses to dietary methionine restriction
Restricting availability of essential amino acids (EAAs) limits aminoacylation of tRNAs by
their cognate EAAs and activates the nutrient-sensing kinase, general control …
their cognate EAAs and activates the nutrient-sensing kinase, general control …
[HTML][HTML] Master regulator activating transcription factor 3 (ATF3) in metabolic homeostasis and cancer
HC Ku, CF Cheng - Frontiers in Endocrinology, 2020 - frontiersin.org
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital
roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the …
roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the …
[HTML][HTML] Activating transcription factor 3 in immune response and metabolic regulation
K Jadhav, Y Zhang - Liver research, 2017 - Elsevier
Abstract Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic adenosine
monophosphate (cAMP)-response element binding protein (CREB) family of transcription …
monophosphate (cAMP)-response element binding protein (CREB) family of transcription …
[HTML][HTML] A lifetime of stress: ATF6 in development and homeostasis
RF Hillary, U FitzGerald - Journal of biomedical science, 2018 - Springer
Background Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-
localised protein and member of the leucine zipper family of transcription factors. Best …
localised protein and member of the leucine zipper family of transcription factors. Best …
Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
Appropriate regulation of the Integrated stress response (ISR) and mTORC1 signaling are
central for cell adaptation to starvation for amino acids. Halofuginone (HF) is a potent …
central for cell adaptation to starvation for amino acids. Halofuginone (HF) is a potent …
[HTML][HTML] ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate
dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine …
dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine …
[HTML][HTML] Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism
TD Baird, RC Wek - Advances in nutrition, 2012 - Elsevier
Regulation of mRNA translation is a rapid and effective means to couple changes in the
cellular environment with global rates of protein synthesis. In response to stresses, such as …
cellular environment with global rates of protein synthesis. In response to stresses, such as …
[HTML][HTML] ATF4-mediated upregulation of REDD1 and Sestrin2 suppresses mTORC1 activity during prolonged leucine deprivation
D Xu, W Dai, L Kutzler, HA Lacko, LS Jefferson… - The Journal of …, 2020 - Elsevier
Background: The protein kinase target of rapamycin (mTOR) in complex 1 (mTORC1) is
activated by amino acids and in turn upregulates anabolic processes. Under nutrient …
activated by amino acids and in turn upregulates anabolic processes. Under nutrient …