The NLRP3 inflammasome is a critical component of innate immunity that defends the host
from microbial infections. However, its aberrant activation contributes to the pathogenesis of …

The NLRP3 inflammasome regulates innate immune and inflammatory responses by
promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Inflammasomes are cytosolic multiprotein complexes that cause the release of biologically
active interleukin‐1β. The best‐characterized inflammasome is the NLRP3 (nucleotide …

The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which
can be initiated in response to various exogenous or endogenous danger signals …

NACHT, LRR (leucine-rich repeat), and PYD (pyrin domain) domain-containing 6 (Nlrp6) is
a member of the NLR (nucleotide-oligomerization domain-like receptor) family that patrols …

Abstract The NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3) inflammasome
is a multimolecular complex that plays a fundamental role in inflammation. Optimal activation …

Many infections and stress signals can rapidly activate the NLRP3 inflammasome to elicit
robust inflammatory responses. This activation requires a priming step, which is thought to …

The NLRP3 inflammasome is central to host defense and implicated in various inflammatory
diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation …

The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain
containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns …