HIF-1 (hypoxia-inducible factor-1), a heterodimeric transcription factor comprising HIF-1α
and HIF-1β subunits, serves as a key regulator of metabolic adaptation to hypoxia. HIF-1 …

p53 is required for hypoxia-induced apoptosisin vivo, although the mechanism by which this
occurs is not known. Conversely, induction of the hypoxia-inducible factor-1 (HIF-1) …

Oxygen sensing and reactivity to changes in the concentration of oxygen is a fundamental
property of cell physiology. The lack of O2 (hypoxia) is transmitted into many adaptive …

The hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that mediates adaptive
cellular responses to decreased oxygen availability (hypoxia). At normoxia, HIF-1α is …

In the presence of oxygen and iron, hypoxia-inducible factor (HIF-1α) is rapidly degraded via
the prolyl hydroxylases (PHD)/VHL pathways. Given striking similarities between p53 and …

Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid
arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer. At …

Hypoxia inducible factor (HIF) is the major transcription factor involved in the regulation of
the cellular response to hypoxia, or low oxygen tensions. Even though HIF-1 function is …

Tumor hypoxia activates hypoxia-inducible factor-1 (HIF-1) and induces the accumulation of
the tumor suppressor p53. HIF-1 signaling stimulates angiogenesis and mediates cellular …

Many human diseases are characterized by the development of tissue hypoxia. Hypoxia-
inducible factor (HIF) is a transcription factor that regulates fundamental cellular processes …

Abstract Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator,
which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 …