Although pain and itch are distinct sensations, most noxious chemicals are not very specific
to one sensation over the other, and recent discoveries are revealing that Trp channels …

Itch (pruritus) is a sensory phenomenon characterized by a (usually) negative affective
component and the initiation of a special behavioral act, ie scratching. Older studies …

Itch is a unique sensation that helps organisms scratch away external threats; scratching
itself induces an immune response that can contribute to more itchiness. Itch is induced …

Mechanistic theories of itch are based on neuronal specificity, stimulus intensity, and
temporal or spatial discharge patterns. Traditionally, these theories are conceptualized as …

The somatosensory system is responsible for processing proprioceptive, thermal, touch, and
pain information from the body surface and internal tissues. The skin is in fact the largest …

Itch-specific neurons have been sought for decades. The existence of such neurons has
been doubted recently as a result of the observation that itch-mediating neurons also …

Itch and pain are closely related but distinct sensations. They share largely overlapping
mediators and receptors, and itch-responding neurons are also sensitive to pain stimuli. Itch …

Abstract In 1905, Henry Head first suggested that transmission of pain-related protopathic
information can be negatively modulated by inputs from afferents sensing innocuous touch …

Itch is an unpleasant cutaneous sensation that can arise following insect bites, exposure to
plant ingredients, and some diseases. Itch can also have idiopathic causes. Itch sensations …

Itch, in particular chronic forms, has been widely recognized as an important clinical
problem, but much less is known about the mechanisms of itch in comparison with other …