Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by
self-immune cells, and the consequent inability of the body to maintain insulin levels for …

Abstract Type 1 diabetes (T1D) is an autoimmune disease resulting in the destruction of the
insulin-producing pancreatic beta cells. Disease progression occurs along a trajectory from …

Abstract Type 1 Diabetes Mellitus (T1DM) is characterized by progressive autoimmune-
mediated destruction of the pancreatic beta-cells leading to insulin deficiency and …

The immune system is tasked with defending the host from a wide array of pathogens and
environmental insults. When uncontrolled, this endeavor may lead to off-target reactivity to …

Type 1 diabetes (T1D) is a chronic autoimmune disease that leads to destruction of
pancreatic β cells, lifelong dependence on insulin, and increased morbidity and mortality …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss
of insulin-producing pancreatic β-cells. The pathogenesis of T1D is complex and …

Summary Type 1 diabetes (T1D) is often considered the prototype organ-specific
autoimmune disease in clinical immunology circles. The key disease features− precise …

A major effort has been on-going to develop immunotherapies to prevent and/or treat type 1
diabetes (T1D). This autoimmune disease is characterized by the selective loss of the insulin …

Advances in our fundamental understanding of how the human diabetes immune response
is activated and regulated coupled with lessons that have been learnt from the most recent …