Considerable emphasis has been placed on maintaining as much simplicity and practicality
as possible. Using this protocol, programmes lacking access to substantial financial …

Background Treatments for uncomplicated falciparum malaria should have high cure rates.
The World Health Organization has recently set a target cure rate of 95% assessed at 28 …

Antimalarial drugs remain the major intervention tool for the global malaria control efforts
that save millions of lives. Nonetheless, emergence and spread of Plasmodium parasites …

To determine the optimum duration of follow-up for the assessment of drug efficacy against
Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with …

The currently used methods for assessing the therapeutic response to antimalarial drugs are
relatively imprecise and insensitive. These methods are inadequate in severe malaria when …

Background Standard methods for defining clinical malaria in intervention trials in endemic
areas do not guarantee that efficacy estimates will be unbiased, and do not indicate whether …

Abstract The Kaplan–Meier (K–M) method is currently the preferred approach to derive an
efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be …

Background Analytical approaches for the interpretation of anti-malarial clinical trials vary
considerably. The aim of this study was to quantify the magnitude of the differences between …

Efficacious antimalarials are a cornerstone of the global effort to control and eliminate
malaria. However, the spread of drug resistance threatens gains achieved over the early …

Based on the five-year field experience of using the 1996 WHO protocol for the assessment
of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas …