There is a growing interest in the targeting of Toll-like receptors (TLRs) for the prevention
and treatment of cancer, rheumatoid arthritis, inflammatory bowel disease and systemic …

Toll-like receptor (TLR) signaling is initiated by dimerization of intracellular Toll/IL-1 receptor
resistance (TIR) domains. For all TLRs except TLR3, recruitment of the adapter, myeloid …

Toll-like receptors (TLRs) are type I transmembrane proteins that are key regulators of both
innate and adaptive immune responses. To protect the host from viral and bacterial threats …

Inflammation is set off when innate immune cells detect infection or tissue injury. Tight
control of the severity, duration, and location of inflammation is an absolute requirement for …

TAK-242 (resatorvid), a small-molecule–specific inhibitor of Toll-like receptor (TLR) 4
signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by …

The family of Toll-like receptors (TLRs) is receiving considerable attention as potential
regulators and controllers of the immune response through their ability to recognize …

Introduction: Toll-like receptors (TLRs) are a crucial part of the innate immunity and present
the first line of defense against pathogens. In humans, there are ten TLRs, with TLR3, 7, 8 …

Toll‐Like Receptors (TLRs) are the innate immunity receptors that play an activating role
when interacting with molecules released by bacteria and viruses (PAMPs, pathogen …

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the
release of critical proinflammatory cytokines that are necessary to activate potent immune …

TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is
involved in the recognition of viral and bacterial pathogens. We previously showed that in …