MEI8Oand threeof the otherradiolabelswere also tested with this anbbody-targetcell
combinadonfor comparison. Results: Iodineconjugatedto antibOdieSby …

Background. Previous experiments indicated that most antibodies binding to cell surface
antigens are internalized gradually and degraded within lysosomes, with a half‐life of …

The effect of using a “residualizing” iodine radiolabel, dilactitol-iodotyramine, for
radioimmunolocalization of antibodies to tumors was investigated. This tracer is designed to …

Radiolabeled antibodies have produced encouraging remissions in patients with
chemotherapy-resistant hematological malignancies; however, the selection of therapeutic …

Antibodies, specifically monoclonal antibodies, are potentially very useful and powerful
carriers of therapeutic agents to target tissues and diagnostic agents. The loading or …

A monoclonal antibody reactive against the human transferrin receptor has been labelled
with the alpha and X ray emitting isotope Astatine 211. The labelling procedure does not …

Scintigraphic studies in animals and in humans have demonstrated uptake of radiolabeled
antibody by both normal and tumor tissue. Normal tissues most commonly visualized are …

1311or 111ln was similar. A bi-phaalc decline of both radiolabeled preparations was
measuredwith initialhalf-lives0. 62 and 0.42 daysfor 1311and1 1Inlabelsandthenwith 1.85 …

Approaches have been developed to improve the localization of radiolabeled monoclonal
antibodies (MAbs) in experimental tumors, to reduce their uptake in normal tissues, and …

The first labeling of antibodies with radioactive isotopes was reported by Pressman [1] in
1948. A radioiodine was employed. Over the next two decades, extensive development of …