The vertebrate immune response involves a complex interplay between different cell types,
mediated in part by interacting cell surface structures. Of the cells involved in the immune …

Recent data on the molecular biology of T cells have given us a detailed view of the genes
and proteins involved in antigen recognition by T cells. T and B cells are responsible for …

T lymphocytes and B lymphocytes, the two major classes of effector cells in the vertebrate
immune system, are capable of recognizing and responding to a virtually infinite range of …

Perspectives Page 1 Perspectives Structure and Function of the T Cell Antigen Receptor Arthur
Weiss Howard Hughes Medical Institute, Division ofRheumatology and Clinical Immunology …

There are significant differences between B-cell and T-cell recognition of antigen. Whereas
B cells bind free antigen, T cells bind antigen that has been internally processed and re …

A defining characteristic of the vertebrate adaptive immune system is its specificity, which
arises from clonally distributed receptors encoded by gene segments that undergo somatic …

T lymphocytes recognize antigen in the context of membrane-bound products of the major
histocompatibility complex (MHC) with exquisite specificity (1-5). This recognition is …

The vertebrate immune response employs two categories of cells that react specifically with
antigens: B lymphocytes react with soluble antigens and T lymphocytes react with antigens …

The genes encoding the alpha and beta chain of the T-cell receptor and the gamma gene
have been cloned, and their structure, organization, ontogeny of expression, pattern of …

The four distinct T-cell antigen receptor polypeptides (α, β, γ, δ) form two different
heterodimers (α: β and γ: δ) that are very similar to immunoglobulins in primary sequence …