Male germ cell apoptosis has been extensively explored in rodents. In contrast, very little is
known about the susceptibility of developing germ cells to apoptosis in response to busulfan …

Apoptosis plays an important role in controlling germ cell numbers and restricting abnormal
cell proliferation during spermatogenesis. The tumor suppressor protein, p53, is highly …

Stem cell factor (SCF) plays an important role in migration, adhesion, proliferation, and
survival of primordial germ cells and spermatogonia during testicular development …

Testicular germ cell apoptosis in the cryptorchid testis is induced by abdominal heat stress.
p53‐dependent apoptosis appears responsible for the initial phase of germ cell loss in …

Germ cell apoptosis is very common during various stages of mammalian testicular
development. However, our understanding of the mechanisms underlying male germ cell …

Elimination of germ cells via apoptosis occurs spontaneously under normal physiologic
conditions and is often heightened after chemical-induced testicular injury. Though many …

Programmed cell death is an important regulatory event in spermatogenesis. However, the
molecular events governing apoptosis have not been characterized. Using the Leydig cell …

Loss of germ cells is very common during various stages of mammalian spermatogenesis.
Although cell death, particularly apoptosis, has been implicated, our understanding of the …

Kit and its ligand stem cell factor (SCF) play a fundamental role in hematopoiesis,
melanogenesis and gametogenesis. Homozygous W v mutant mice with a mutation in kit …

This review aims at characterising the process of male germ cell death, focusing on the role
of testicular steroid hormones, the role of two important induction pathways of apoptosis, the …