Erlotinib, Afatinib, and WZ4002 are quinazoline derivative compounds and classified as first,
second, and third-generation EGFR inhibitor. All inhibitors have been given directly to …

EGFR is the cell-surface receptor. Its overexpression or overactivity has been associated
with a number of cancers, including breast, lung, ovarian, and anal cancers. Many …

The epidermal growth factor receptor (EGFR) signaling pathway plays an important role in
cell growth, proliferation, differentiation, and other physiological processes, which makes the …

QSAR modelling on Thirty (34) novel quinazoline derivatives (EGFR WT inhibitors) as non-
small cell lung cancer (NSCLC) agents was performed to develop a model with good …

Background: Gefitinib (lressa) is the most prescribed drug, highly effective to treat nonsmall
cell lung cancer; primarily it was considered that targeted therapy is a kinase inhibitor. The …

Cancer is a malignant disease and causing the high rate of mortality and morbidity. Current
strategies for the treatment include chemotherapy, radiation therapy and surgery. There are …

Objective Abutilon indicum is a medicinal plant belonging to the Malvaceae family. The
current study has been developed to detect Abutilon indicum bio-activity to produce an …

Epidermal growth factor receptor (EGFR) is the first growth factor receptor proposed as a
target for cancer therapy. Molecular modeling protocols like molecular docking, molecular …

A series of novel 4-anilino quinazoline derivatives were taken based on the literature study
and optimized with Autodock version 4.2 and molecular dynamics (MD) protocol to …

Objectives The study focused on developing novel series of compounds based on the
inhibition of epidermal growth factor receptor tyrosine kinase (EGFR-TK) as one of the most …