The expression of HIGD2A is dependent on oxygen levels, glucose concentration, and cell
cycle progression. This gene encodes for protein HIG2A, found in mitochondria and the …

Mitochondrial respiratory supercomplex formation requires HIG2A protein, which also has
been associated with cell proliferation and cell survival under hypoxia. HIG2A protein …

Cancer, the main cause of human deaths in the modern world is a group of diseases.
Anticancer drug discovery is a challenge for scientists because of involvement of multiple …

Mitochondria play a central role in cellular energy conversion, metabolism, and cell
proliferation. The regulation of mitochondrial function by HIGD1A, which is located on the …

Abstract Hypoxia‐inducible factor‐1 (HIF‐1), consisting of oxygen‐sensitive HIF‐1α and
constitutively expressed HIF‐1β subunits, is a master transcriptional activator for cellular …

Abstract HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several
cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic …

Background Hypoxia contributes to cancer progression through various molecular
mechanisms and hepatocellular carcinoma (HCC) is one of the most hypoxic malignancies …

Hypoxia has been recognized as one of the fundamentally important features of solid tumors
and plays a critical role in various cellular and physiologic events, including cell …

Abstract Background The Hypoxia inducible gene domain family member 2A (HIGD2A)
protein is indispensable for the assembly of the mitochondrial respiratory supercomplex …

Hypoxia inducible factor 1-alpha (HIF-1α) is commonly up-regulated in multiple human
malignancies, and plays an important role in tumor metabolism through regulating glycolytic …