Fundamental human traits, such as language and bipedalism, are associated with a range
of anatomical adaptations in craniofacial shaping and skeletal remodeling. However, it is …

Disruption of FOXP2, a gene encoding a forkhead‐domain transcription factor, causes a
severe developmental disorder of verbal communication, involving profound articulation …

Highlights•Mutations of the FOXP2 gene cause a severe speech and language
disorder.•Mice with Foxp2 disruptions have provided valuable insights into its …

Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …

It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution due to effects on aspects of speech …

Most vertebrates communicate acoustically, but few, among them humans, dolphins and
whales, bats, and three orders of birds, learn this trait. FOXP2 is the first gene linked to …

The FOXP2 gene is important for the development of proper speech motor control in
humans. However, the role of the gene in general vocal behavior in other mammals …

Humans and songbirds are two of the rare animal groups that modify their innate
vocalizations. The identification of FOXP2 as the monogenetic locus of a human speech …

Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-
described examples of monogenic speech and language disorders. Acquisition of proficient …

In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as
the basis of an inherited speech and language disorder suffered by members of the family …