Featured Application QSAR model for the determination of gut permeability of 228
pharmacological drugs at different pH conditions. Abstract The present study aims at …

A QSAR model was developed for predicting intestinal drug permeability, one of the most
important parameters when evaluating compounds in drug discovery projects. First, a set of …

Permeability is important in governing the ability of drug substances to transport across
gastrointestinal membrane and also crucial for proper drug distribution to pharmacological …

The influence of pH on human intestinal absorption is frequently not considered in early
drug discovery studies in the modelling and subsequent prediction of intestinal absorption …

In silico models for membrane permeability have been based on values measured for single
pH. Depending on the diet (fasted/fed state) and part of human intestine the range of pH …

Because the oral route of drug delivery is incomparable, screening of intestinal permeability
and absorption of drug candidates is a critical stage before clinical trials for time and cost …

Solubility and permeability are recognized as key parameters governing drug intestinal
absorption and represent the basis for biopharmaceutics drug classification. The …

The accuracy of the provisional estimation of the Biopharmaceutics Classification System
(BCS) is heavily influenced by the permeability measurement. In this study, several …

A system for predicting apparent bidirectional permeability (P app) across Caco-2 cells of
diverse chemicals has been reported. The present study aimed to investigate the …

ABSTRACT AB/HIA is a “soft” filter for identifying compounds with poor intestinal membrane
permeability. The analyzed data set included over 1000 drug‐like compounds with …