Background Recent advances in transcriptome sequencing have enabled the discovery of
thousands of long non-coding RNAs (lncRNAs) across many species. Though several …

Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a
multitude of pathways across species, but it remains challenging to understand which of …

Background Metazoans transcribe many long non-coding RNAs (lncRNAs) that are poorly
conserved and whose function remains unknown. This has raised the questions of what …

Background Long considered to be the building block of life, it is now apparent that protein is
only one of many functional products generated by the eukaryotic genome. Indeed, more of …

Long noncoding RNAs (lncRNAs) comprise a diverse class of transcripts that structurally
resemble mRNAs but do not encode proteins. Recent genome-wide studies in humans and …

Background Recent advances in genomewide studies have revealed the abundance of long
non-coding RNAs (lncRNAs) in mammalian transcriptomes. The ENCODE Consortium has …

Background The role of long non-coding RNAs (lncRNAs) in controlling gene expression
has garnered increased interest in recent years. Sequencing projects, such as Fantom3 for …

A large proportion of functional sequence within mammalian genomes falls outside protein-
coding exons and can be transcribed into long RNAs. However, the roles in mammalian …

With the abundant mammalian lncRNAs identified recently, a comprehensive annotation
resource for these novel lncRNAs is an urgent need. Since its first release in November …

Eukaryote genomes encode a surprisingly large number of noncoding transcripts. Around
two-thirds of human transcribed loci do not encode protein, and many are intergenic and …