Traumatic brain injury: what is a favorable outcome?

DA Zuckerman, JT Giacino, YG Bodien - Journal of neurotrauma, 2022 - liebertpub.com
Traumatic brain injury (TBI) results in disparate outcomes ranging from persistent disorders
of consciousness to symptom resolution. Despite the breadth and complexity of TBI …

Recovery trajectories and long-term outcomes in traumatic brain injury: a secondary analysis of the phase 3 citicoline brain injury treatment clinical trial

RC Puffer, JK Yue, M Mesley, JB Billigen, J Sharpless… - World neurosurgery, 2019 - Elsevier
Background Prospects for recovery after traumatic brain injury (TBI) are often
underestimated, potentially leading to withdrawal of care in the comatose TBI patient who …

Addressing the challenges of obtaining functional outcomes in traumatic brain injury research: missing data patterns, timing of follow-up, and three prognostic models

LR Zelnick, LJ Morrison, SM Devlin… - Journal of …, 2014 - liebertpub.com
Traumatic brain injury (TBI) is common and debilitating. Randomized trials of interventions
for TBI ideally assess effectiveness by using long-term functional neurological outcomes, but …

Outcome assessment in traumatic brain injury clinical trials and prognostic studies

M Sherer, T Roebuck-Spencer… - The Journal of head …, 2010 - journals.lww.com
Large numbers of investigations have sought to evaluate prediction of outcome after
traumatic brain injury (TBI) and the effectiveness of interventions designed to address post …

Optimizing outcome assessment in multicenter TBI trials: perspectives from TRACK-TBI and the TBI Endpoints Development Initiative

YG Bodien, M McCrea, S Dikmen… - The Journal of head …, 2018 - journals.lww.com
Traumatic brain injury (TBI) is a global public health problem that affects the long-term
cognitive, physical, and psychological health of patients, while also having a major impact …

Traumatic brain injury: an international knowledge-based approach

GT Manley, AIR Maas - Jama, 2013 - jamanetwork.com
Traumatic brain injury (TBI) is a multifaceted condition, not an event. Traumatic brain injury is
broadly defined as an alteration in brain function or other evidenceofbrainpathologycausedbyanexter …

Favorable functional recovery in severe traumatic brain injury survivors beyond six months

TE Wilkins, SR Beers, AJ Borrasso, J Brooks… - Journal of …, 2019 - liebertpub.com
Favorable long-term functional outcomes after severe traumatic brain injury (TBI) may be
underestimated. We analyzed 24-month functional outcomes from a consecutive series of …

Validating multi-dimensional outcome assessment using the traumatic brain injury common data elements: an analysis of the TRACK-TBI pilot study sample

LD Nelson, J Ranson, AR Ferguson… - Journal of …, 2017 - liebertpub.com
Abstract The Glasgow Outcome Scale-Extended (GOSE) is often the primary outcome
measure in clinical trials for traumatic brain injury (TBI). Although the GOSE's capture of …

Functional outcomes over the first year after moderate to severe traumatic brain injury in the prospective, longitudinal TRACK-TBI study

MA McCrea, JT Giacino, J Barber, NR Temkin… - JAMA …, 2021 - jamanetwork.com
Importance Moderate to severe traumatic brain injury (msTBI) is a major cause of death and
disability in the US and worldwide. Few studies have enabled prospective, longitudinal …

Timing of withdrawal of life-sustaining therapies in severe traumatic brain injury: impact on overall mortality

VA McCredie, AS Alali, W Xiong… - Journal of trauma and …, 2016 - journals.lww.com
BACKGROUND The care of patients with severe traumatic brain injury (TBI) is complex and
confounded by uncertainty in prognoses. Studies have demonstrated significant …