As obesity and diabetes reach epidemic proportions in the developed world, the role of
insulin resistance and its consequences are gaining prominence. Understanding the role of …

Insulin orchestrates physiological responses to ingested nutrients; however, although it
elicits widely ramifying metabolic and trophic responses from diverse tissues,'insulin …

Recent research has greatly expanded the domain of insulin action. The classical action of
insulin is the control of glucose metabolism through the dual feedback loop linking plasma …

The past 20 years have witnessed a remarkable increase in our knowledge of the cellular
and molecular mechanisms that underlie the diverse actions of insulin, the central hormone …

Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus:
Problems and Prospects | Endocrine Reviews | Oxford Academic Skip to Main Content …

Summary. Type 2 diabetes is a heterogeneous condition that is not attributable to a single
pathophysiological mechanism. In general, both insulin resistance and impaired insulin …

Following the discovery of insulin by Banting and Best in 1922, it was widely assumed that
human diabetes was due exclusively to a deficiency in the secretion of the hormone …

Insulin resistance is perceived as deleterious, associated with conditions as the metabolic
syndrome, type 2 diabetes mellitus and critical illness. However, insulin resistance is …

The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Insulin resistance underpins the link between obesity and most of its associated metabolic
disorders including type 2 diabetes, fatty liver disease, dyslipidaemia and cardiovascular …