Premature ovarian insufficiency (POI) is defined as the cessation of ovarian function under
the age of 40 years and is characterized by amenorrhea, hypoestrogenism, and elevated …

Primary ovarian insufficiency (POI), also known as premature ovarian failure (POF), is
defined as more than six months of cessation of menses before the age of 40 years, with two …

Primary ovarian insufficiency (POI) is a critical fertility defect characterized by an anticipated
and silent impairment of the follicular reserve, but its pathogenesis is largely unexplained …

Purpose Primary ovarian insufficiency (POI) is a heterogeneous, multifactorial disorder.
Though genetic anomalies, infections, autoimmune disorder and hormonal imbalance are …

BACKGROUND: Mitochondrial biogenesis and bioenergetics play an important role in
oocyte maturation and embryo development. We have investigated the relationship between …

Primary ovarian insufficiency (POI) is defined by the loss or dysfunction of ovarian follicles
associated with amenorrhea before the age of 40. Symptoms include hot flashes, sleep …

Premature ovarian insufficiency (POI) is a common endocrine disorder featured by the triad
constituting of amenorrhea for at least four months, to date, the molecular pathogenesis of …

OBJECTIVE: To evaluate the relationship between mitochondrial gene expression of
oocytes/embryos and their fertilizability in unfertilized oocytes, arrested embryos, and …

Various pathogenic factors can lead to oogenesis failure and seriously affect both female
reproductive health and fertility. Genetic factors play an important role in folliculogenesis and …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …